产品
编 号：F174600
分子式：C18H23Cl3NO3P
分子量：438.71
分子式：C18H23Cl3NO3P
分子量：438.71
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 149184-22-5
产品详情
生物活性：
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research.
体内研究：
CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice.Animal Model:Cdkl5 +/Y and Cdkl5 -/Y male mice (2-month-old)
Dosage:0.5 mg/kg
Administration:i.p.; once
Result:Altered NOR recognition memory in Cdkl5 -/Y mice
体外研究：
In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR).
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research.
体内研究：
CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice.Animal Model:Cdkl5 +/Y and Cdkl5 -/Y male mice (2-month-old)
Dosage:0.5 mg/kg
Administration:i.p.; once
Result:Altered NOR recognition memory in Cdkl5 -/Y mice
体外研究：
In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备