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编 号：F177430
分子式：C55H96N14O13
分子量：1161.44
分子式：C55H96N14O13
分子量：1161.44
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CAS No: 1507930-57-5
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生物活性：
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.
体内研究：
Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. Animal Model:C57/BL6 mice
Dosage:25 mg/kg
Administration:IV; 10 min before ligation
Result:Significantly reduced the infarct size by approximately one-fifth.
体外研究：
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.
体内研究：
Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. Animal Model:C57/BL6 mice
Dosage:25 mg/kg
Administration:IV; 10 min before ligation
Result:Significantly reduced the infarct size by approximately one-fifth.
体外研究：
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
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