产品
编 号：F181015
分子式：C14H10Cl2KNO2
分子量：334.24
分子式：C14H10Cl2KNO2
分子量：334.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
560
In-stock
100mg
800
In-stock
250mg
1600
In-stock
结构图
CAS No: 15307-81-0
产品详情
生物活性：
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
体内研究：
Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.Animal Model:Male Sprague-Dawley rats (150±200 g)
Dosage:3 mg/kg
Administration:Oral administration, b.i.d., for 5 days
Result:Resulted in a significant increase in faecal 51Cr excretion.
Animal Model:Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model
Dosage:10 mg/kg
Administration:Administered via oral route just prior to induction of inflammation
Result:Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).
体外研究：
Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM. Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs) death in a concentration-dependent manner.Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
体内研究：
Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.Animal Model:Male Sprague-Dawley rats (150±200 g)
Dosage:3 mg/kg
Administration:Oral administration, b.i.d., for 5 days
Result:Resulted in a significant increase in faecal 51Cr excretion.
Animal Model:Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model
Dosage:10 mg/kg
Administration:Administered via oral route just prior to induction of inflammation
Result:Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).
体外研究：
Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM. Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs) death in a concentration-dependent manner.Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.
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