产品
编 号:F183880
分子式:C34H33FeN4O5
分子量:633.49
产品类型
结构图
CAS No: 15489-90-4
联系客服
产品详情
生物活性:
Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins. Hematin can be used for the research of acute porphyrias and cancer.
体内研究:
Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g).
体外研究:
Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin.Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml.Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml).Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin.