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编 号:F022043
分子式:C19H18BrN3O2
分子量:400.27
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1mg
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生物活性:
AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5.

体内研究:
AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats.

体外研究:
AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages.
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