产品
编 号：F197096
分子式：C22H25Cl2NO3
分子量：422.34
分子式：C22H25Cl2NO3
分子量：422.34
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CAS No: 1638667-81-8
产品详情
生物活性：
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor.
体内研究：
DETQ (10 mg/kg；腹腔注射；一次) 改善雄性人源化 D1 受体敲入小鼠的亚慢性 Phencyclidine 诱导的物体识别记忆缺陷并增强皮质乙酰胆碱流出。Animal Model:Mice genetically modified to express the human D1 receptor ("hD1 mice")
Dosage:10 mg/kg
Administration:i.p.; once
Result:Ameliorated subchronic Phencyclidine-induced object recognition memory deficits.
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor.
体内研究：
DETQ (10 mg/kg；腹腔注射；一次) 改善雄性人源化 D1 受体敲入小鼠的亚慢性 Phencyclidine 诱导的物体识别记忆缺陷并增强皮质乙酰胆碱流出。Animal Model:Mice genetically modified to express the human D1 receptor ("hD1 mice")
Dosage:10 mg/kg
Administration:i.p.; once
Result:Ameliorated subchronic Phencyclidine-induced object recognition memory deficits.
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