产品
编 号:F199416
分子式:C61H83N15O10
分子量:1186.41
产品类型
结构图
CAS No: 166188-11-0
联系客服
产品详情
生物活性:
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).
体内研究:
Tyrosinase (206-214) is administered intranasally (i.n.; 45 μL; weekly for three weeks) into HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) shows an accumulation of murine CD3+ and CD8+ cells around the bronchioles. All A24Tg immunized with Tyrosinase (206-214) died after lethal A/HK483 infection.
体外研究:
Tyrosinase (206-214), human (AFLPWHRLF) can be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma.