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编 号：F023991
分子式：C9H19NO2
分子量：173.25
分子式：C9H19NO2
分子量：173.25
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CAS No: 10581-38-1
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生物活性：
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats.
体内研究：
Triacetonamine (200 mg、300 mg、400 mg/Kg/天；灌胃；2 天) monohydrate 显示在剂量为 300 mg/Kg/天和 400 mg/Kg/天会出现典型的 ALF 肝肠病理学，而 400 mg/Kg/day组的死亡率较高。Animal Model:Rats (half male and female, 6-8 weeks old, 200?±?10 g)
Dosage:200 mg, 300 mg, 400 mg/Kg
Administration:Gavage; daily; 2 days
Result:Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats.
体内研究：
Triacetonamine (200 mg、300 mg、400 mg/Kg/天；灌胃；2 天) monohydrate 显示在剂量为 300 mg/Kg/天和 400 mg/Kg/天会出现典型的 ALF 肝肠病理学，而 400 mg/Kg/day组的死亡率较高。Animal Model:Rats (half male and female, 6-8 weeks old, 200?±?10 g)
Dosage:200 mg, 300 mg, 400 mg/Kg
Administration:Gavage; daily; 2 days
Result:Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.
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