产品
编 号：F205652
分子式：C8H8ClNO3
分子量：201.61
分子式：C8H8ClNO3
分子量：201.61
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 170846-74-9
产品详情
生物活性：
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.
体内研究：
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.Animal Model:Adult Sprague-Dawley male rats weighing 280-320 g
Dosage:250 nM
Administration:Injection; for 7 days
Result:Reduced significantly cerebral lesion volume.
体外研究：
CHPG (10-500?μM; 24?hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment. CHPG (0.5?mM; 30?mins ) protects BV2 cells against SO2-induced apoptosis. CHPG (0.5?mM; 30?mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.
体内研究：
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.Animal Model:Adult Sprague-Dawley male rats weighing 280-320 g
Dosage:250 nM
Administration:Injection; for 7 days
Result:Reduced significantly cerebral lesion volume.
体外研究：
CHPG (10-500?μM; 24?hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment. CHPG (0.5?mM; 30?mins ) protects BV2 cells against SO2-induced apoptosis. CHPG (0.5?mM; 30?mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
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