产品
编 号：F207834
分子式：C106H184N40O26
分子量：2434.85
分子式：C106H184N40O26
分子量：2434.85
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 172998-24-2
产品详情
生物活性：
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria.
体内研究：
Buforin II (intravenously a single dose, 1 mg/kg) has potent antibacterial activity that effectively reduces lethality and leads to a significant reduction in plasma endotoxin and cytokine concentrations in male Wistar rat model of sepsis.Animal Model:Male Wistar rats weighing 200 to 300 g with A. baumannii?ATCC 19606
Dosage:1 mg/kg
Administration:Intravenously a single dose
Result:Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively.
Animal Model:Male Wistar rats weighing 200 to 300 g with the multiresistant strain
Dosage:1 mg/kg
Administration:Intravenously a single dose
Result:Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively.
体外研究：
Buforin II inhibits A. baumanniiATCC 19606 and multiresistant strains with the similar MIC values of 8 mg/L.
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria.
体内研究：
Buforin II (intravenously a single dose, 1 mg/kg) has potent antibacterial activity that effectively reduces lethality and leads to a significant reduction in plasma endotoxin and cytokine concentrations in male Wistar rat model of sepsis.Animal Model:Male Wistar rats weighing 200 to 300 g with A. baumannii?ATCC 19606
Dosage:1 mg/kg
Administration:Intravenously a single dose
Result:Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively.
Animal Model:Male Wistar rats weighing 200 to 300 g with the multiresistant strain
Dosage:1 mg/kg
Administration:Intravenously a single dose
Result:Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively.
体外研究：
Buforin II inhibits A. baumanniiATCC 19606 and multiresistant strains with the similar MIC values of 8 mg/L.
产品资料
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