产品
编 号：F208270
分子式：C15H15NO4S
分子量：305.35
分子式：C15H15NO4S
分子量：305.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
288
In-stock
5mg
632
In-stock
10mg
1012
In-stock
25mg
1924
In-stock
50mg
3078
In-stock
100mg
4924
In-stock
结构图
CAS No: 173436-66-3
产品详情
生物活性：
MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.
体内研究：
MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model. MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice.Animal Model:Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells
Dosage:10, 20 mg/kg
Administration:I.p. dailyfor 2 weeks
Result:Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.
体外研究：
MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells. MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells. MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells. MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells. MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells.
MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.
体内研究：
MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model. MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice.Animal Model:Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells
Dosage:10, 20 mg/kg
Administration:I.p. dailyfor 2 weeks
Result:Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.
体外研究：
MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells. MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells. MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells. MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells. MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells.
产品资料
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