产品
编 号：F213128
分子式：C5H4N4NaO
分子量：159.1
分子式：C5H4N4NaO
分子量：159.1
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 17795-21-0
产品详情
生物活性：
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.
体内研究：
Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse.Animal Model:20-30 g, male Swiss Albino mice
Dosage:39 mg/kg
Administration:P.o.; daily for 21 successive days
Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.
Animal Model:30-40 g, male adult Swiss albino mice
Dosage:10, 50, 100, 200, 400 mg/kg
Administration:I.p.
Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.
体外研究：
Allopurinol sodium (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol sodium (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells.
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.
体内研究：
Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse.Animal Model:20-30 g, male Swiss Albino mice
Dosage:39 mg/kg
Administration:P.o.; daily for 21 successive days
Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.
Animal Model:30-40 g, male adult Swiss albino mice
Dosage:10, 50, 100, 200, 400 mg/kg
Administration:I.p.
Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.
体外研究：
Allopurinol sodium (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol sodium (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells.
产品资料
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