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编 号:F213836
分子式:C17H19N5O8
分子量:421.36
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生物活性:
ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access.

体内研究:
ROS 234, centrally injected, significantly shortens pentobarbital narcosis.
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