产品
编 号：F214385
分子式：C9H15ClN2O2
分子量：218.68
分子式：C9H15ClN2O2
分子量：218.68
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 178419-42-6
产品详情
生物活性：
AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.
体内研究：
AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction.AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats.Animal Model:Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen
Dosage:1, 2.5, 5 mg/kg
Administration:I.p. twice daily from day 20 until day 26
Result:Ameliorated arthritis and delayed onset of disease.Reduced erosive disease, cartilage degradation and synovial inflammation.Reduced TNFα levels in plasma and synovial tissue.
体外研究：
AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor.AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages.
AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.
体内研究：
AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction.AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats.Animal Model:Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen
Dosage:1, 2.5, 5 mg/kg
Administration:I.p. twice daily from day 20 until day 26
Result:Ameliorated arthritis and delayed onset of disease.Reduced erosive disease, cartilage degradation and synovial inflammation.Reduced TNFα levels in plasma and synovial tissue.
体外研究：
AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor.AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages.
产品资料
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