产品
编 号：F217945
分子式：C24H16F4N6O2
分子量：496.42
分子式：C24H16F4N6O2
分子量：496.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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2mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1799753-84-6
产品详情
生物活性：
BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.
体内研究：
BAY-876 (口服给药；1.5-4.5 mg/kg/天，持续 28 天) 对小鼠的致瘤性产生明显的剂量依赖性抑制。Animal Model:Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts
Dosage: 1.5, 3, 4.5 mg/kg
Administration:Oral administration; daily; for 28 days
Result:Caused a clear dose-dependent inhibition of tumorigenicity.
体外研究：
BAY-876 (25-75 nM；24 和 72 小时) 具有生长抑制作用，并导致 SKOV-3 和 OVCAR-3 细胞数量呈剂量依赖性减少。
BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.
体内研究：
BAY-876 (口服给药；1.5-4.5 mg/kg/天，持续 28 天) 对小鼠的致瘤性产生明显的剂量依赖性抑制。Animal Model:Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts
Dosage: 1.5, 3, 4.5 mg/kg
Administration:Oral administration; daily; for 28 days
Result:Caused a clear dose-dependent inhibition of tumorigenicity.
体外研究：
BAY-876 (25-75 nM；24 和 72 小时) 具有生长抑制作用，并导致 SKOV-3 和 OVCAR-3 细胞数量呈剂量依赖性减少。
产品资料
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