产品
编 号：F225330
分子式：C25H23F3N2O5S
分子量：520.52
分子式：C25H23F3N2O5S
分子量：520.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1809427-19-7
产品详情
生物活性：
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
体内研究：
DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient.Animal Model:6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106).
Dosage:5 mg/kg.
Administration:Oral gavage for 4 weeks.
Result:Showed activity in inhibiting tumor growth.
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
体内研究：
DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient.Animal Model:6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106).
Dosage:5 mg/kg.
Administration:Oral gavage for 4 weeks.
Result:Showed activity in inhibiting tumor growth.
产品资料
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