产品
编 号：F226334
分子式：C22H28ClN3O3S
分子量：449.99
分子式：C22H28ClN3O3S
分子量：449.99
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CAS No: 181936-98-1
产品详情
生物活性：
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo.
体内研究：
KC 12291 hydrochloride (0.63 mg/kg，口服；1 次) 对麻醉兔模型有明显的抗缺血活性。KC 12291 hydrochloride (60 mg/kg，口服) 在雌性和雄性小鼠中的血浆 Cmax 值分别为 1.3 和 1.4 μg/mL，血浆的 Tmax 值将近 2 小时。Animal Model:Anesthetized rabbit model
Dosage:0.16, 0.63 mg/kg
Administration:Oral administration (p.o.); Once
Result:Significantly attenuated the coronary occlusion produced marked ST segment elevation about 68 % at 0.63 mg/kg.
体外研究：
KC 12291 hydrochloride (1 μM) 降低了大约 60 % 大鼠心室心肌细胞的 Na+ 电流峰 。
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo.
体内研究：
KC 12291 hydrochloride (0.63 mg/kg，口服；1 次) 对麻醉兔模型有明显的抗缺血活性。KC 12291 hydrochloride (60 mg/kg，口服) 在雌性和雄性小鼠中的血浆 Cmax 值分别为 1.3 和 1.4 μg/mL，血浆的 Tmax 值将近 2 小时。Animal Model:Anesthetized rabbit model
Dosage:0.16, 0.63 mg/kg
Administration:Oral administration (p.o.); Once
Result:Significantly attenuated the coronary occlusion produced marked ST segment elevation about 68 % at 0.63 mg/kg.
体外研究：
KC 12291 hydrochloride (1 μM) 降低了大约 60 % 大鼠心室心肌细胞的 Na+ 电流峰 。
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