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编 号：F229962
分子式：C26H37NO2
分子量：395.58
分子式：C26H37NO2
分子量：395.58
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CAS No: 183718-77-6
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生物活性：
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect.
体内研究：
AM404 (1-5?mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.Animal Model:Adult male Sprague-Dawley rats (250-300?g)
Dosage:2.5-10?mg/kg
Administration:Intraperitoneal (i.p.)
Result:Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.
体外研究：
AM404 reduces C6 glioma cell proliferation with IC50 values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect.
体内研究：
AM404 (1-5?mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.Animal Model:Adult male Sprague-Dawley rats (250-300?g)
Dosage:2.5-10?mg/kg
Administration:Intraperitoneal (i.p.)
Result:Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.
体外研究：
AM404 reduces C6 glioma cell proliferation with IC50 values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.
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