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编 号:F230560
分子式:C22H30O6
分子量:390.47
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Bakkenolide B is isolated from petasites japonicas leaves and has?anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma.

体内研究:
Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice.Animal Model:Ovalbumin-induced asthma mice
Dosage:1 mg/ml
Administration:Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result:Exhibited anti-allergic effects in mice.

体外研究:
Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner.Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages.
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