产品
编 号：F231545
分子式：C13H10N2O
分子量：210.23
分子式：C13H10N2O
分子量：210.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
660
In-stock
1mg
272
In-stock
5mg
600
In-stock
10mg
855
In-stock
50mg
2533
In-stock
100mg
3800
In-stock
结构图
CAS No: 18550-98-6
产品详情
生物活性：
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer.
体内研究：
3PO (0.07 mg/g; i.p. once per day for 14 days) inhibits the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice.3PO (0.07 mg/g; i.p. three sequential daily injections followed by 3 off days for 14 days) inhibits the tumor growth in BALB/c athymic mice.3PO (0.07 mg/g; i.p. two daily injections followed a 7-day rest for 14 days) inhibits the tumor growth in BALB/c athymic mice.3PO (0.07 mg/g; i.p. once) inhibits Fru-2,6-BP and glucose uptake in C57Bl/6 mice.Animal Model:Female C57Bl/6 mice with Lewis lung carcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g once a day; for 14 days
Result:Suppressed the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice compared to the control group.
Animal Model:Female BALB/c athymic mice with MDA-MB231 human breast adenocarcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g three sequential daily injections of either DMSO or 3PO followed by 3 off days; for 14 days
Result:Suppressed xenograft tumorigenic growth of MDA-MB231 cells compared with the controls.
Animal Model:Female BALB/c athymic mice with HL-60 leukemia xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g two daily injections followed a 7-day rest; for 14 days
Result:Suppressed xenograft tumorigenic growth of HL-60 leukemia compared with the controls, especially from the second administration cycle.
Animal Model:Female C57Bl/6 mice with Lewis lung carcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; once
Result:Decreased Fru-2,6-BP and glucose uptake in C57Bl/6 mice compared to control group.
体外研究：
3PO (0-33 μM; 0-36 h) inhibits Jurkat cells proliferation by influence cell cycle.3PO (10 μM/L; 0-36 h) suppresses glycolytic flux to lactate in Jurkat cells.3PO (10 μM/L; 0-36 h) inhibits cellular proliferation of transformed tumor cell lines.
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer.
体内研究：
3PO (0.07 mg/g; i.p. once per day for 14 days) inhibits the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice.3PO (0.07 mg/g; i.p. three sequential daily injections followed by 3 off days for 14 days) inhibits the tumor growth in BALB/c athymic mice.3PO (0.07 mg/g; i.p. two daily injections followed a 7-day rest for 14 days) inhibits the tumor growth in BALB/c athymic mice.3PO (0.07 mg/g; i.p. once) inhibits Fru-2,6-BP and glucose uptake in C57Bl/6 mice.Animal Model:Female C57Bl/6 mice with Lewis lung carcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g once a day; for 14 days
Result:Suppressed the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice compared to the control group.
Animal Model:Female BALB/c athymic mice with MDA-MB231 human breast adenocarcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g three sequential daily injections of either DMSO or 3PO followed by 3 off days; for 14 days
Result:Suppressed xenograft tumorigenic growth of MDA-MB231 cells compared with the controls.
Animal Model:Female BALB/c athymic mice with HL-60 leukemia xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; 0.07 mg/g two daily injections followed a 7-day rest; for 14 days
Result:Suppressed xenograft tumorigenic growth of HL-60 leukemia compared with the controls, especially from the second administration cycle.
Animal Model:Female C57Bl/6 mice with Lewis lung carcinoma xenografts
Dosage:0.07 mg/g
Administration:Intraperitoneal injection; once
Result:Decreased Fru-2,6-BP and glucose uptake in C57Bl/6 mice compared to control group.
体外研究：
3PO (0-33 μM; 0-36 h) inhibits Jurkat cells proliferation by influence cell cycle.3PO (10 μM/L; 0-36 h) suppresses glycolytic flux to lactate in Jurkat cells.3PO (10 μM/L; 0-36 h) inhibits cellular proliferation of transformed tumor cell lines.
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