产品
编 号：F239080
分子式：C31H36F3N7O5
分子量：643.66
分子式：C31H36F3N7O5
分子量：643.66
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 191868-14-1
产品详情
生物活性：
BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
体内研究：
BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels.Animal Model:Adult male Chbb:Thom rats weighing between 300 and 340 g
Dosage:30 μg
Administration:bilateral paraventricular nucleus injection
Result:Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.
Animal Model:7-week-old C57BL/6JAusb mice
Dosage:0.5?μM
Administration:p.o.
Result:Significantly increased serum insulin levels.
BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
体内研究：
BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels.Animal Model:Adult male Chbb:Thom rats weighing between 300 and 340 g
Dosage:30 μg
Administration:bilateral paraventricular nucleus injection
Result:Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.
Animal Model:7-week-old C57BL/6JAusb mice
Dosage:0.5?μM
Administration:p.o.
Result:Significantly increased serum insulin levels.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备