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编 号：F239589
分子式：C15H12KN5O4
分子量：365.39
分子式：C15H12KN5O4
分子量：365.39
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CAS No: 192564-13-9
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生物活性：
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species.
体内研究：
Leteprinim (30 或 60 mg/kg，腹膜内注射，持续 7 天) potassium 可保护大鼠免受红藻氨酸 (12 mg/kg) 诱导的海马神经元兴奋性毒性。Leteprinim (60 mg/kg, i.p.) potassium 在年轻和年老小鼠中提高工作记忆。Leteprinim (60 mg/kg; 腹腔注射; 单剂量) potassium 显着减少缺氧缺血性脑损伤幼鼠中凋亡神经元的数量。Animal Model:Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)
Dosage:60 mg/kg
Administration:IP; single dosage
Result:The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
体外研究：
Leteprinim (5-50 ng/mL，24 和 48 小时) potassium 可增强神经递质释放，增加 PC12 细胞中突触素的分泌。
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species.
体内研究：
Leteprinim (30 或 60 mg/kg，腹膜内注射，持续 7 天) potassium 可保护大鼠免受红藻氨酸 (12 mg/kg) 诱导的海马神经元兴奋性毒性。Leteprinim (60 mg/kg, i.p.) potassium 在年轻和年老小鼠中提高工作记忆。Leteprinim (60 mg/kg; 腹腔注射; 单剂量) potassium 显着减少缺氧缺血性脑损伤幼鼠中凋亡神经元的数量。Animal Model:Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)
Dosage:60 mg/kg
Administration:IP; single dosage
Result:The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
体外研究：
Leteprinim (5-50 ng/mL，24 和 48 小时) potassium 可增强神经递质释放，增加 PC12 细胞中突触素的分泌。
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