产品
编 号:F239602
分子式:C30H31ClN2O3
分子量:503.03
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM.

体外研究:
BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM
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