产品
编 号：F241645
分子式：C9H10ClNO3
分子量：215.63
分子式：C9H10ClNO3
分子量：215.63
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 194085-75-1
产品详情
生物活性：
Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy.
体内研究：
Carisbamate (10, 30, 60 mg/kg; i.p.; single) dose dependently reduces the expression of spike-and-wave discharges (SWD) in absence seizures rat model.Carisbamate (20, 30 mg/kg; i.p.; single) shows no wild running episode or tonic seizure occurres in any of the rats tested.Animal Model:Male genetic absence epilepsy rat (absence seizures model).
Dosage:10, 30, 60 mg/kg
Administration:Intraperitoneal injection; single.
Result:Completely inhibited SWD when at 60 mg/kg after 120 min, and restored the duration of SWD to the control level when at 30 mg/kg after 100 min.
Animal Model:Male Wistar audiogenic sensitive rat (convulsive seizures model).
Dosage:10, 20, 30 mg/kg
Administration:Intraperitoneal injection; single.
Result:Showed no wild running episode or tonic seizure occurred in any of the rats tested when at 20 and 30 mg/kg.Increased by 327% the latency to the tonic seizure that still occurred in the six of eight rats studied when at 10 mg/kg.
体外研究：
Carisbamate (200 μM; 12 h) exhibits antiepileptic effects on SREDs model of hippocampal cells.Carisbamate (200 μM; 24 h) shows long lasting effects on the hippocampal neurons that are independent from antiepileptic effects in vitro.Carisbamate not only inhibits the development and expression of SREDs in the majority of neurons, but also decreases seizure frequency and duration in the few neurons that still has an occasional epileptiform event.Carisbamate (200 μM) shows neuroprotective effects on hippocampal cells with SE (status epilepticus)-like injury.
Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy.
体内研究：
Carisbamate (10, 30, 60 mg/kg; i.p.; single) dose dependently reduces the expression of spike-and-wave discharges (SWD) in absence seizures rat model.Carisbamate (20, 30 mg/kg; i.p.; single) shows no wild running episode or tonic seizure occurres in any of the rats tested.Animal Model:Male genetic absence epilepsy rat (absence seizures model).
Dosage:10, 30, 60 mg/kg
Administration:Intraperitoneal injection; single.
Result:Completely inhibited SWD when at 60 mg/kg after 120 min, and restored the duration of SWD to the control level when at 30 mg/kg after 100 min.
Animal Model:Male Wistar audiogenic sensitive rat (convulsive seizures model).
Dosage:10, 20, 30 mg/kg
Administration:Intraperitoneal injection; single.
Result:Showed no wild running episode or tonic seizure occurred in any of the rats tested when at 20 and 30 mg/kg.Increased by 327% the latency to the tonic seizure that still occurred in the six of eight rats studied when at 10 mg/kg.
体外研究：
Carisbamate (200 μM; 12 h) exhibits antiepileptic effects on SREDs model of hippocampal cells.Carisbamate (200 μM; 24 h) shows long lasting effects on the hippocampal neurons that are independent from antiepileptic effects in vitro.Carisbamate not only inhibits the development and expression of SREDs in the majority of neurons, but also decreases seizure frequency and duration in the few neurons that still has an occasional epileptiform event.Carisbamate (200 μM) shows neuroprotective effects on hippocampal cells with SE (status epilepticus)-like injury.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备