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编 号：F244645
分子式：C16H14F3N3OS
分子量：353.36
分子式：C16H14F3N3OS
分子量：353.36
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CAS No: 196965-14-7
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生物活性：
SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
体内研究：
SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801. SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidineAnimal Model:Male Sprague Dawley rats (250–360 g)
Dosage:0.1~1 mg/kg
Administration:I.p.
Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:Male Sprague Dawley rats (250–360 g)
Dosage:1 mg/kg
Administration:I.p.
Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
体内研究：
SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801. SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidineAnimal Model:Male Sprague Dawley rats (250–360 g)
Dosage:0.1~1 mg/kg
Administration:I.p.
Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:Male Sprague Dawley rats (250–360 g)
Dosage:1 mg/kg
Administration:I.p.
Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
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