产品
编 号：F245206
分子式：C2H5NaO3S2
分子量：164.18
分子式：C2H5NaO3S2
分子量：164.18
产品类型
规格
价格
是否有货
500mg
280
In-stock
5g
384
In-stock
10g
632
In-stock
结构图
CAS No: 19767-45-4
产品详情
生物活性：
Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide.
体内研究：
Mesna (150 mg/kg；单次 ip) 保护大鼠脑免受外伤。Mesna (200 mg/kg；单次 ip) 减弱顺铂诱导的卵巢功能障碍大鼠的损伤。Animal Model:Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)
Dosage:150 mg/kg
Administration:A single i.p.
Result:Decreased tissue malondialdehyde levels.Increased the activity of glutathione peroxidase and superoxide dismutase.Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.Protected the brain tissues well from injury.
体外研究：
Mesna (1-1000 μM) 以剂量依赖性方式降低 H2O2、HOCl 和 OH? 浓度，IC50 在无细胞实验中分别为 32、21 和 305 μM。
Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide.
体内研究：
Mesna (150 mg/kg；单次 ip) 保护大鼠脑免受外伤。Mesna (200 mg/kg；单次 ip) 减弱顺铂诱导的卵巢功能障碍大鼠的损伤。Animal Model:Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)
Dosage:150 mg/kg
Administration:A single i.p.
Result:Decreased tissue malondialdehyde levels.Increased the activity of glutathione peroxidase and superoxide dismutase.Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.Protected the brain tissues well from injury.
体外研究：
Mesna (1-1000 μM) 以剂量依赖性方式降低 H2O2、HOCl 和 OH? 浓度，IC50 在无细胞实验中分别为 32、21 和 305 μM。
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