产品
编 号：F250173
分子式：C33H38N4O6
分子量：586.68
分子式：C33H38N4O6
分子量：586.68
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CAS No: 20298-86-6
产品详情
生物活性：
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.
体内研究：
Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用。Animal Model:Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes
Dosage:15 mg/kg
Administration:In diet for 2 weeks
Result:Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.
体外研究：
Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化，并产生较长的诱导期。Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化。
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.
体内研究：
Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用。Animal Model:Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes
Dosage:15 mg/kg
Administration:In diet for 2 weeks
Result:Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.
体外研究：
Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化，并产生较长的诱导期。Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化。
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