产品
编 号：F252513
分子式：C20H25F3N6O2S
分子量：470.51
分子式：C20H25F3N6O2S
分子量：470.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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询价
结构图
CAS No: 2055757-40-7
产品详情
生物活性：
SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM.
体内研究：
SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume.SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days.Animal Model:Six-week old female athymic NU/NU mice were inoculated subcutaneously with Detroit-562 pharyngeal carcinoma cells.
Dosage:20, 40, and 80 mg/kg
Administration:Oral gavage; twice daily
Result:Demonstrated a clear dose-dependent reduction in tumor volume.
体外研究：
SHP394 inhibits Caco-2 cells proliferation with the IC50 of 297 nM.SHP394 exhibits antiproliferation activity against the Detroit-562 pharyngeal carcinoma cell line in vitro (IC50= 1.38 μM) .SHP394 decreases p-ERK with an IC50 of 18 nM KYSE520 cells.
SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM.
体内研究：
SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume.SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days.Animal Model:Six-week old female athymic NU/NU mice were inoculated subcutaneously with Detroit-562 pharyngeal carcinoma cells.
Dosage:20, 40, and 80 mg/kg
Administration:Oral gavage; twice daily
Result:Demonstrated a clear dose-dependent reduction in tumor volume.
体外研究：
SHP394 inhibits Caco-2 cells proliferation with the IC50 of 297 nM.SHP394 exhibits antiproliferation activity against the Detroit-562 pharyngeal carcinoma cell line in vitro (IC50= 1.38 μM) .SHP394 decreases p-ERK with an IC50 of 18 nM KYSE520 cells.
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