产品
编 号：F254594
分子式：C15H20Cl2N6O
分子量：371.26
分子式：C15H20Cl2N6O
分子量：371.26
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CAS No: 207556-62-5
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生物活性：
NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.
体内研究：
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.Animal Model:Obese (fa/fa) and lean (FA/?) Zucker rats
Dosage:3.72 mg/kg
Administration:Oral administration
Result:Led to inhibition of plasma DPP-IV activity.
体外研究：
NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.
体内研究：
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.Animal Model:Obese (fa/fa) and lean (FA/?) Zucker rats
Dosage:3.72 mg/kg
Administration:Oral administration
Result:Led to inhibition of plasma DPP-IV activity.
体外研究：
NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
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