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编 号：F255174
分子式：C27H29NO10
分子量：527.52
分子式：C27H29NO10
分子量：527.52
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CAS No: 20830-81-3
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生物活性：
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
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