产品
编 号：F255513
分子式：C24H28N4O3
分子量：420.5
分子式：C24H28N4O3
分子量：420.5
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2088113-98-6
产品详情
生物活性：
AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of 500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer.
体内研究：
AZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage.Animal Model:Nude mice
Dosage:50 and 100 mg/kg
Administration:Oral gavage; 50 and 100 mg/kg twice a day
Result:Exhibited exposure over IC50 at 0.046 μM in brain only for 2-3 hours.
体外研究：
AZ31 (0.3-3 μM; 1 h) affects phosphorylation of a panel of ATM targets.AZ31 (10 μM; 1 h) affects stabilization of p53 in H2228 lung cancer cells after radiation.
AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of 500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer.
体内研究：
AZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage.Animal Model:Nude mice
Dosage:50 and 100 mg/kg
Administration:Oral gavage; 50 and 100 mg/kg twice a day
Result:Exhibited exposure over IC50 at 0.046 μM in brain only for 2-3 hours.
体外研究：
AZ31 (0.3-3 μM; 1 h) affects phosphorylation of a panel of ATM targets.AZ31 (10 μM; 1 h) affects stabilization of p53 in H2228 lung cancer cells after radiation.
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