产品
编 号：F255557
分子式：C32H36ClN9O2S
分子量：646.21
分子式：C32H36ClN9O2S
分子量：646.21
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规格
价格
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结构图
CAS No: 2088518-50-5
产品详情
生物活性：
Dot1L-IN-1 is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of <0.1 nM. Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively.
体外研究：
Dot1L-IN-1 (类似物 7) 有效抑制携带致癌 MLL-AF4 融合的人 MLL 重排白血病细胞系 MV4-11 的增殖 (IC50=5 nM)[1 ]。
Dot1L-IN-1 is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of <0.1 nM. Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively.
体外研究：
Dot1L-IN-1 (类似物 7) 有效抑制携带致癌 MLL-AF4 融合的人 MLL 重排白血病细胞系 MV4-11 的增殖 (IC50=5 nM)[1 ]。
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