产品
编 号：F259651
分子式：C20H19ClN6O2
分子量：410.86
分子式：C20H19ClN6O2
分子量：410.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
询价
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10mg
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25mg
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结构图
CAS No: 2097938-51-5
产品详情
生物活性：
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
体内研究：
R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.Animal Model:6-8 weeks female C3H/HeN mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection
Result:Displayed none indication of toxicity.
体外研究：
R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
体内研究：
R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.Animal Model:6-8 weeks female C3H/HeN mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection
Result:Displayed none indication of toxicity.
体外研究：
R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .
产品资料
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