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编 号：F270611
分子式：C10H12Cl2F3N3
分子量：302.12
分子式：C10H12Cl2F3N3
分子量：302.12
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CAS No: 210821-63-9
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生物活性：
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C?receptor agonist and exhibits pEC50?values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A?and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
体内研究：
Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.Animal Model:Male Wistar rats
Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:Had a dose-related antipanic-like effect in SD-rat.
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C?receptor agonist and exhibits pEC50?values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A?and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
体内研究：
Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.Animal Model:Male Wistar rats
Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:Had a dose-related antipanic-like effect in SD-rat.
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