产品
编 号:F271772
分子式:C46H64O2
分子量:649
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5mg
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10mg
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50mg
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100mg
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生物活性:
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS).

体内研究:
Menaquinone-7 (18.1 mg/100 g 饮食;在动物饲料中;24 天) 预防去卵巢大鼠骨质流失。Animal Model:Female Wistar rats (5-week-old; ovariectomized (OVX) rats model).
Dosage:18.1 mg/100 g diet
Administration:In animal feedings; 24 days
Result:Had a preventive effect on OVX-induced bone loss.

体外研究:
Menaquinone-7 (0.01-10 μM;7 天) 抑制骨髓培养物中的破骨细胞样细胞形成。 Menaquinone-7 (10 μM) 促进生腱蛋白 C 的表达并增加 MC3T3E1 细胞中磷酸化的 Smad1 水平。Menaquinone-7 (1,10 μM) 在植物雌激素染料木黄酮 (1, 10 μM) 存在的情况下显着增强对股骨钙含量的合成代谢作用。
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