产品
编 号：F271924
分子式：C17H13BrClF2IN2O2
分子量：557.56
分子式：C17H13BrClF2IN2O2
分子量：557.56
产品类型
规格
价格
是否有货
1mg
274
In-stock
5mg
720
In-stock
10mg
1280
In-stock
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 212631-67-9
产品详情
生物活性：
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
体内研究：
PD184161 reduces tumor xenograft P-ERK levels in 3-12 hours after an oral dose.PD184161 (300 mg/kg; orogastric gavage twice daily for 38 days) significantly suppresses tumor engraftment and initial growth.PD184161 (30 mg/kg; i.p.; single injection) produces depressive-like behavior.PD184161 (500 μg/kg; intravenous injection) prevents the progression of neurological deficits and brain damage after stroke.Animal Model:Hep3B tumor xenografts BALB/c athymic nude mice
Dosage:300 mg/kg
Administration:Orogastric gavage twice daily for 38 days
Result:Decreased the early tumor growth.
Animal Model:Male, 6 weeks C57Bl/6 mice
Dosage:500 μg/kg
Administration:intravenously in 30 min before MCAO or PTZ administration
Result:Prevented the progression of neurological deficits and brain damage after stroke.
Animal Model:C57Bl/6 mice
Dosage:30 mg/kg
Administration:i.p., single injection
Result:Produced depressive-like behavior.
体外研究：
PD184161 (1-20 μM; 24, 48, or 72 hours) inhibits cell proliferation and induces apoptosis in a time and concentration dependent manner.PD184161 (0.1 and 1.0 μM; 1 hour) inhibits ERK1,2 phosphorylation.PD184161 (5 μM; 30 min) prevents the toxic effects of bicuculline.
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
体内研究：
PD184161 reduces tumor xenograft P-ERK levels in 3-12 hours after an oral dose.PD184161 (300 mg/kg; orogastric gavage twice daily for 38 days) significantly suppresses tumor engraftment and initial growth.PD184161 (30 mg/kg; i.p.; single injection) produces depressive-like behavior.PD184161 (500 μg/kg; intravenous injection) prevents the progression of neurological deficits and brain damage after stroke.Animal Model:Hep3B tumor xenografts BALB/c athymic nude mice
Dosage:300 mg/kg
Administration:Orogastric gavage twice daily for 38 days
Result:Decreased the early tumor growth.
Animal Model:Male, 6 weeks C57Bl/6 mice
Dosage:500 μg/kg
Administration:intravenously in 30 min before MCAO or PTZ administration
Result:Prevented the progression of neurological deficits and brain damage after stroke.
Animal Model:C57Bl/6 mice
Dosage:30 mg/kg
Administration:i.p., single injection
Result:Produced depressive-like behavior.
体外研究：
PD184161 (1-20 μM; 24, 48, or 72 hours) inhibits cell proliferation and induces apoptosis in a time and concentration dependent manner.PD184161 (0.1 and 1.0 μM; 1 hour) inhibits ERK1,2 phosphorylation.PD184161 (5 μM; 30 min) prevents the toxic effects of bicuculline.
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