产品
编 号：F273169
分子式：C36H40N2O6
分子量：596.71
分子式：C36H40N2O6
分子量：596.71
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CAS No: 21446-35-5
产品详情
生物活性：
Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities.
体外研究：
Guattegaumerine (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) significantly increases cell viability at 1.25 and 2.5μM; and guattegaumerine pretreatment significantly inhibits LDH efflux.Guattegaumerine (2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) markedly reduces the oxidative stress-induced apoptosis in rat cortical neurons when compares with the control group.Guattegaumerine (1.25-2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) decreases H2O2 and KCl induced Ca[2+]i increase in cortical neurons.
Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities.
体外研究：
Guattegaumerine (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) significantly increases cell viability at 1.25 and 2.5μM; and guattegaumerine pretreatment significantly inhibits LDH efflux.Guattegaumerine (2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) markedly reduces the oxidative stress-induced apoptosis in rat cortical neurons when compares with the control group.Guattegaumerine (1.25-2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) decreases H2O2 and KCl induced Ca[2+]i increase in cortical neurons.
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