产品
编 号:F276116
分子式:C27H29N5
分子量:423.55
产品类型
结构图
CAS No: 218136-59-5
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产品详情
生物活性:
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.
体内研究:
SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.Animal Model:Male mice (12- or 15-week-old)
Dosage:0, 10, 30, and 100 mg/kg per day
Administration:Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.
Result:Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
体外研究:
SC-26196 (200?nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.