产品
编 号:F280716
分子式:C16H13N5
分子量:275.31
产品类型
结构图
CAS No: 2234272-10-5
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产品详情
生物活性:
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease. AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究:
AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.AP-C5 potentiates cAMP signaling by PDE inhibition.AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.