产品
编 号：F280783
分子式：C27H46O2
分子量：402.65
分子式：C27H46O2
分子量：402.65
产品类型
规格
价格
是否有货
5mg
询价
询价
结构图
CAS No: 22348-64-7
产品详情
生物活性：
Cholest-5-ene-3?,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3?,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models.
体内研究：
Cholest-5-ene-3?,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加。在大鼠中的药代动力学分析RouteDose (mg/kg)Cmax (ng/mL)Tmax (h)AUCt (ng·h/mL)AUC (ng·h/mL)T1/2 (h)Extent of tritium exchange (%)
i.v.5022.40.081741958.12.8
p.o.507.5495.21046.41.2
Animal Model:Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)
Dosage:30 mg/kg/day
Administration:Oral gavage; 3 weeks consecutively
Result:Decreased body weight gain significantly after 1 week treatment.Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
体外研究：
Cholest-5-ene-3?,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响。
Cholest-5-ene-3?,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3?,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models.
体内研究：
Cholest-5-ene-3?,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加。在大鼠中的药代动力学分析RouteDose (mg/kg)Cmax (ng/mL)Tmax (h)AUCt (ng·h/mL)AUC (ng·h/mL)T1/2 (h)Extent of tritium exchange (%)
i.v.5022.40.081741958.12.8
p.o.507.5495.21046.41.2
Animal Model:Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)
Dosage:30 mg/kg/day
Administration:Oral gavage; 3 weeks consecutively
Result:Decreased body weight gain significantly after 1 week treatment.Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
体外研究：
Cholest-5-ene-3?,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响。
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