产品
编 号：F281295
分子式：C19H13ClFN3O2
分子量：369.78
分子式：C19H13ClFN3O2
分子量：369.78
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2241838-28-6
产品详情
生物活性：
SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity.
体内研究：
SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice.Animal Model:Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)
Dosage:20, 50 mg/kg/day
Administration:P.O. daily for 6 weeks
Result:Significantly reduced IL-6 and insulin levels.
SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity.
体内研究：
SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice.Animal Model:Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)
Dosage:20, 50 mg/kg/day
Administration:P.O. daily for 6 weeks
Result:Significantly reduced IL-6 and insulin levels.
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