产品
编 号：F281570
分子式：C21H24BrFN2O2
分子量：435.33
分子式：C21H24BrFN2O2
分子量：435.33
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
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50mg
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结构图
CAS No: 2244579-87-9
产品详情
生物活性：
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.
体内研究：
CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)
Dosage:1, 5, 10, 20 mg/kg
Administration:P.o.
Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
体外研究：
CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.
体内研究：
CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)
Dosage:1, 5, 10, 20 mg/kg
Administration:P.o.
Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
体外研究：
CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.
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