产品
编 号：F281583
分子式：C24H26N2O3S
分子量：422.54
分子式：C24H26N2O3S
分子量：422.54
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
询价
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50mg
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100mg
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询价
结构图
CAS No: 2244678-29-1
产品详情
生物活性：
TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.
体外研究：
TH-257 表现出良好的生化和细胞效力。但其极快的体外清除速度使其不适合作为潜在的体内工具。
TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.
体外研究：
TH-257 表现出良好的生化和细胞效力。但其极快的体外清除速度使其不适合作为潜在的体内工具。
产品资料
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