产品
编 号：F281749
分子式：C83H114N18O23S2
分子量：1796.05
分子式：C83H114N18O23S2
分子量：1796.05
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2247635-23-8
产品详情
生物活性：
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids.
体外研究：
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100?nM.Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1?μM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50?nM.Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 μM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function.
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids.
体外研究：
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100?nM.Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1?μM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50?nM.Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 μM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function.
产品资料
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