产品
编 号：F282097
分子式：C22H20F2N2O4
分子量：414.4
分子式：C22H20F2N2O4
分子量：414.4
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CAS No: 2254001-81-3
产品详情
生物活性：
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
体内研究：
ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h).Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model
Dosage:2?mg/kg (Pharmacokinetic Analysis)
Administration:PO
Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
体内研究：
ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h).Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model
Dosage:2?mg/kg (Pharmacokinetic Analysis)
Administration:PO
Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.
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