产品
编 号：F282164
分子式：CH2Cl2Na2O6P2
分子量：288.86
分子式：CH2Cl2Na2O6P2
分子量：288.86
产品类型
规格
价格
是否有货
50mg
148
In-stock
100mg
240
In-stock
250mg
480
In-stock
结构图
CAS No: 22560-50-5
产品详情
生物活性：
Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases.
体内研究：
Clodronic acid disodium salt (6.25-25 mg/kg；口服；每日一次，持续 28 天) 在 12.5 和 25 mg/kg 的剂量下略微减轻后爪肿胀。Animal Model:Male Lewis rats, aged 7 weeks
Dosage:6.25, 12.5, and 25 mg/kg
Administration:P.o.; daily for 28 days
Result:Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
体外研究：
Clodronic acid disodium salt 通过阻止 ADP 在通过吸收内化后易位到线粒体中，诱导破骨细胞快速凋亡。因此，ATP 的产生受到抑制，通过将细胞色素 C 释放到细胞质中诱导细胞凋亡。
Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases.
体内研究：
Clodronic acid disodium salt (6.25-25 mg/kg；口服；每日一次，持续 28 天) 在 12.5 和 25 mg/kg 的剂量下略微减轻后爪肿胀。Animal Model:Male Lewis rats, aged 7 weeks
Dosage:6.25, 12.5, and 25 mg/kg
Administration:P.o.; daily for 28 days
Result:Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
体外研究：
Clodronic acid disodium salt 通过阻止 ADP 在通过吸收内化后易位到线粒体中，诱导破骨细胞快速凋亡。因此，ATP 的产生受到抑制，通过将细胞色素 C 释放到细胞质中诱导细胞凋亡。
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