产品
编 号：F282463
分子式：C19H12Cl2N4O3
分子量：415.23
分子式：C19H12Cl2N4O3
分子量：415.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2262452-06-0
产品详情
生物活性：
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
体内研究：
RU.521 (5 mg/kg；腹腔注射一次) 减轻小鼠败血症的症状。Animal Model:Male 8-week-old male mice with LPS injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg once
Result:Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
体外研究：
RU.521 (0.1 nM-1000 μM；72 h) 抑制巨噬细胞中 dsDNA 诱导的信号传导。RU.521 (0-100 μM；24 h) 选择性抑制 cGAS 介导的信号传导。
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
体内研究：
RU.521 (5 mg/kg；腹腔注射一次) 减轻小鼠败血症的症状。Animal Model:Male 8-week-old male mice with LPS injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg once
Result:Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
体外研究：
RU.521 (0.1 nM-1000 μM；72 h) 抑制巨噬细胞中 dsDNA 诱导的信号传导。RU.521 (0-100 μM；24 h) 选择性抑制 cGAS 介导的信号传导。
产品资料
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