产品
编 号：F284334
分子式：C3H8NO5P
分子量：169.07
分子式：C3H8NO5P
分子量：169.07
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CAS No: 23052-80-4
产品详情
生物活性：
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively.
体内研究：
L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice.
体外研究：
L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively.L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus. L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM).L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively).
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively.
体内研究：
L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice.
体外研究：
L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively.L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus. L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM).L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively).
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