产品
编 号：F287192
分子式：C18H10N2O
分子量：270.28
分子式：C18H10N2O
分子量：270.28
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CAS No: 23749-58-8
产品详情
生物活性：
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research.
体外研究：
AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) 可诱导 AhR WT 和 AhR KO 的 MDA-MB-468 细胞周期停滞并抑制克隆生成。AHR agonist 3 (0-10 μΜ; 72 小时) 可使乳腺癌细胞，而非正常乳腺上皮细胞或非致瘤细胞发生 AhR 依赖性凋亡和生长抑制，并通过 AhR 抑制 TNBC 干细胞生长。
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research.
体外研究：
AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) 可诱导 AhR WT 和 AhR KO 的 MDA-MB-468 细胞周期停滞并抑制克隆生成。AHR agonist 3 (0-10 μΜ; 72 小时) 可使乳腺癌细胞，而非正常乳腺上皮细胞或非致瘤细胞发生 AhR 依赖性凋亡和生长抑制，并通过 AhR 抑制 TNBC 干细胞生长。
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