产品
编 号:F287903
分子式:C23H34O5
分子量:390.51
产品类型
结构图
CAS No: 23930-37-2
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生物活性:
Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception.
体内研究:
Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet.Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats.Animal Model:Inbred Wistar-derived colony female rats (intramuscularly injected with 20 μg/100g oestradiol benzoate)
Dosage:Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate
Administration:i.m.
Result:Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion.
Animal Model:Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)
Dosage:14 mL/kg
Administration:i.p.; single dosage
Result:Decreased serum concentrations of LH.